The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products
نویسندگان
چکیده
ABSTRACT Non-targeted screening of drugs present in herbal products, known as "legal high" drugs and in hair as a biological matrix commonly used in toxicological investigations was accomplished with the use of high pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). In total, 25 and 14 therapeutical drugs and psychoactive substances/metabolites were detected in investigated hair samples and herbal products, respectively. We demonstrate that the HPLC-Q-TOF methodology seems to be a powerful tool in the qualitative analysis applied in identification of these designer drugs, thus enabling a laboratory to stay-up-to-date with the drugs that are being sold as legal high products on black market. GRAPHICAL ABSTRACT
منابع مشابه
Simple and rapid screening procedure for 143 new psychoactive substances by liquid chromatography-tandem mass spectrometry.
In recent years, many new psychoactive substances (NPS) from several drug classes have appeared on the drug market. These substances, also known as 'legal highs', belong to different chemical classes. Despite the increasing number of NPS, there are few comprehensive screening methods for their detection in biological specimens. In this context, the purpose of this study was to develop a fast an...
متن کاملAn investigation of the stability of emerging new psychoactive substances.
The evolving nature of new psychoactive substances (NPS) - often referred to as 'legal highs', 'designer drugs' or 'bath salts' - presents an evolving challenge for toxicologists. Apart from the detection and identification of these compounds, further analytical challenges may arise from the presence of possible metabolites or degradation products which may have to be considered when devising a...
متن کاملHigh Times: an Ethnography of Young Adult Drug Use
This research explores the phenomenon of ‘legal highs’ or Novel Psychoactive Substances (NPS), directing substantial focus towards the exploration of user attraction. Whilst legal high research is expanding, the topic of legal highs still remains a relatively under-researched topic. In particular, research concerning the user is in short supply, as policy makers remain detached from the importa...
متن کاملLimited use of novel psychoactive substances in South London nightclubs.
BACKGROUND There has been significant media interest in the use of novel psychoactive substances (also known as 'legal highs') and reports in the medical literature of toxicity associated with their use. However, most surveys of recreational drug use focus on classical drugs such as cocaine and ecstasy, and there is limited information on how commonly emerging novel psychoactive substances are ...
متن کاملAnalysis of psychoactive and intoxicating substances in legal highs.
"Legal highs" known also as "smarts", "legal drugs" or "boosters" contain in their composition psychoactive substances the production, sale and possession of which are not prohibited in legislation. They are offered for sale under the cover of collectors' items, a salt bath, aroma sticks, or plant fertilizer. Marketing was the reason for such high sales of these "highs" in Poland. The phenomeno...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 147 شماره
صفحات -
تاریخ انتشار 2016